Paul Bieniasz joins TWiV to discuss his lab’s discovery that the coronavirus nuclease NSP15 cuts viral RNA into oligonucleotides that are reinserted elsewhere in the viral RNA, generating insertion mutations at a frequency above 10⁻³ per genome, including new furin cleavage sites at the spike S1/S2 junction.
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Links for this episode- Support science education at MicrobeTV Genetic innovation in coronaviruses driven by a viral nuclease (bioRxiv) Letters read on TWiV 1357 Timestamps by Jolene Ramsey. Thanks!
Kathy – Jurassic Museum of Asturias
Alan – Grand Central Winter, by Lee Stringer
Vincent – How to Choose REAL Extra Virgin Olive Oil: A Practical Guide and How to Tell if Your Olive Oil is Fake! Quick Kitchen Tip!
Shirley – I Told You So! by Matt Kaplan
Intro music is by Ronald Jenkees
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