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Jason Calacanis
This Week in Startups
Technology
English
Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
Website
Episodes
300
03 February 2026
Where early-stage founders MUST focus to success | E2244
This Week In Startups is made possible by:Quadratic - http://quadratic.ai/twistToday’s show: Don’t get distracted! Here are the MOST CRUCIAL aspects of running a startup, where founders need to keep their full and uninterrupted focus.- Make sure you’re saving up your cash- Why you need to just get started and build SOMETHING- Trust and reliability is EVERYTHING for new products- Why distribution...
1 h 7 min
03 February 2026
SpaceX + xAI deal gets us one step closer to Musk Industries | E2243
This Week In Startups is made possible by:Uber - http://uber.com/twistDeel - http://deel.com/twistNorthwest Registered Agent - https://www.northwestregisteredagent.com/twistToday’s show: SpaceX is buying xAI, forming a mega-corp that plans to launch data centers into SPACE. Will Tesla also join up, fulfilling Elon’s destiny to become real-life Tony Stark, with his own Musk Industries? Jason and...
1 h 2 min
31 January 2026
How OpenClaw (Clawdbot) Is Rewriting the Way Our Team Works with Rahul Sood | E2242
This Week In Startups is made possible by:Deel - http://deel.com/twistLinkedIn Jobs - http://linkedin.com/twistNorthwest Registered Agent - https://www.northwestregisteredagent.com/twistToday’s show: On Today’s action packed episode of This Week in Startups, our team is going full AI!Jason is joined by Oliver Korzen and Lukas Durand from the LAUNCH team, alongside Rahul Sood, founder/CEO of...
1 h 28 min
29 January 2026
How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241
This Week In Startups is made possible by:Gusto - http://Gusto.com/twistZite - http://zite.com/twistCircle.so - http://circle.so/twistGuest links: Andrew Duffy, Founder and CEO, http://sparkplug.app — Retail incentives and brand partnerships platformFord Smith, Founder of http://Ultranative.com — Investing in transformative startupsSocrates Rosenfeld, Founder and CEO of http://iheartjane.com —...
55 min
27 January 2026
Clawdbot is an inflection point in AI history | E2240
This Week In Startups is made possible by:Quo - http://quo.com/TWiSTLemon IO - https://lemon.io/twistNorthwest Registered Agent - https://www.northwestregisteredagent.com/twistToday’s show: Jason is back from Davos and Tokyo! We are jumping right back in with a group of Clawdbot power users: Alex Finn, Matt Von Horn, and Dan Penguine.Clawdbot is a hot open source AI project that lets users...
1 h 2 min
24 January 2026
Why You’ll Choose an AI Doctor (feat. Fred Almeida and Max Weiss) | E2239
This Week In Startups is made possible by:Sentry.io - sentry.io/twistHubspot - clickhubspot.com/twist2Northwest Registered Agent - https://northwestregisteredagent.com/twistToday’s show:One day soon, you might consult an AI general practitioner about your health, and then the computer will recommend human specialists to take up your case.On TWiST Tokyo, Jason chats with Fred Almeida — founder and...
1 h 3 min
21 January 2026
From Blood Transfusions to Burritos, How Zipline is Automating Delivery | E2238
This Week In Startups is made possible by:Northwest Registered Agent - www.northwestregisteredagent.com/twistCrusoe Cloud - https://crusoe.ai/savingsLinkedIn Jobs - http://linkedIn.com/twistToday’s show: On today’s TWIST episode, Alex interviews two of the top startup co-founders: Keller Cliffton of Zipline and Anastasis Germanidis of Runway. Zipline announced its $600 million raise at a $7.6...
1 h 3 min
20 January 2026
How startups suddenly became “cool” in Japan (feat. Shin Takamiya of Globis Capital) | E2237
This Week In Startups is made possible by:Circle.so - http://Circle.so/twistDeel - http://deel.com/twistUber AI Solutions - http://uber.com/twistToday’s show:Not long ago, promising young Japanese graduates wanted to go work for the largest, most established, and even oldest corporations: Sony, Mitsubishi, and the like. But now, just over the last few years, more and more Japanese people are...
57 min
16 January 2026
Avoiding buzzwords and marketing-speak (feat. Thomas McInerney) | E2236
This Week In Startups is made possible by:Lemon.io - https://lemon.io/twistDeel - http://deel.com/twistLinkedIn Jobs - http://linkedIn.com/twistToday’s show: Some pitches sound just like ads… and it’s a huge red flag for investors.On our latest edition of TWiST Tokyo, Jason welcomes legendary angel investor (and long-time friend of the pod) Thomas McInerney. His list of investments reads like a...
1 h 3 min
14 January 2026
Japan’s Startup Revolution (feat. Kathy Matsui) | E2235
This Week In Startups is made possible by:Every.io - http://every.io/LinkedIn Jobs - https://www.linkedin.com/twistZite - http://zite.com/twistToday’s show: Why do 40% of Japanese students want to build a company rather than join the corporate workforce?On TWiST, Jason considers this question along with special guest Kathy Matsui, general partner of the global VC fund MPower Partners.Their...
1 h 7 min