#508: ASCVD Risk & Lipids Update! PREVENT, ApoB, Lp(a) + Next-Gen Therapies
15 December 2025

#508: ASCVD Risk & Lipids Update! PREVENT, ApoB, Lp(a) + Next-Gen Therapies

The Curbsiders Internal Medicine Podcast

About
Master cardiovascular disease prevention! Learn how to apply the new PREVENT risk calculator, use the CPR framework for risk reclassification, and interpret ApoB and Lp(a) in modern lipid management. We’re joined by Dr. Laurence Sperling to break down what’s new in ASCVD risk assessment and prevention.



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Show Segments






    Intro
    Case 1 from Kashlak 
    Risk assessment framework
    ApoB and Non-HDL cholesterol
    Lipoprotein(a) and its importance
    The PREVENT risk score and its implications
    Statins and other lipid lowering therapies
    The role of diet and lifestyle in lipid management
    Case 2 from Kashlak
    Familial Hypercholesterolemia diagnosis and management
    Key takeaways
    Outro




Credits






    Producer, Writer, Shownotes, Infographic, and Cover art: Ben Furman, MPH 
    Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP   
    Reviewer: Leah Witt, MD
    Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
    Technical Production: PodPaste
    Guest: Laurence Sperling, MD 




Disclosures



Dr. Sperling reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.





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