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Malaria remains a leading public health challenge in South Sudan, driven by climate, displacement, and low uptake of preventive measures. In this interview of our Weekly Health Information updates, ahead of World Malaria Day, a World Health Organization's Dr Mustafa Lasu explains why cases persist, the dangers of self-medication, and the rise of drug resistance. With new tools including vaccines and mass net distribution, the focus is on prevention, early testing, and community action, as authorities push for stronger, coordinated efforts to reduce infections and save lives.