S1, E14 - Orr Inbar, CEO Quant Health - AI Simulations of Clinical Trials

Practical AI in Healthcare just released one of our most eye-opening conversations yet, featuring Orr Inbar, CEO & Co-Founder of QuantHealth.

QuantHealth is pushing the boundaries of what’s possible in clinical development with AI-driven clinical trial simulation. Orr walked us through how modern deep learning, massive biological knowledge graphs, and patient-level real-world data can now simulate clinical trials with 80–90% accuracy — across dozens of indications, modalities, and trial phases.

In our conversation, we cover:

• How QuantHealth models patient-drug interactions at massive scale
• Why trial design is still the most critical (and fixable) failure point in drug development
• How simulation is becoming the new starting point for protocols
• What AI-first trial design could mean for speed, cost, and reducing avoidable trial failures
• Where the field is headed in the next 5–10 years — including the provocative question of how far simulation can replace human trials

Orr also discusses the acceleration of biological data, the maturity of real-world data, and transformer-based AI — the perfect storm that made this moment possible.

This is one of the best deep dives yet into the practical future of drug development.