Welcome to Cardiology Today – Recorded September 29, 2025. This episode summarizes 5 key cardiology studies on topics like Western diet and diastole. Key takeaway: Smoking Ignites Atrial Fibrillation Via Inflammasome.
Article Links:
Article 1: Hemodynamic Monitoring and Management of the Hypotensive Out-of-Hospital Cardiac Arrest Patient in the Adult Intensive Care Unit. (European heart journal. Acute cardiovascular care)
Article 2: On the Measurement of the Vortex Formation Time in the Left Ventricle. (American journal of physiology. Heart and circulatory physiology)
Article 3: Cigarette Smoking Induces NLRP3 Inflammasome Activation in Atrial Fibrillation Patients. (American journal of physiology. Heart and circulatory physiology)
Article 4: Objective assessment of cardiac function using patient-specific biophysical modeling based on cardiovascular MRI combined with catheterization. (American journal of physiology. Heart and circulatory physiology)
Article 5: Conventional Tobacco and Electronic Cigarettes Differentially Affect Cardiovascular Health in Male and Female Mice. (American journal of physiology. Heart and circulatory physiology)
Full episode page: https://podcast.explainheart.com/podcast/smoking-ignites-atrial-fibrillation-via-inflammasome-09-29-25/
Featured Articles
Article 1: Hemodynamic Monitoring and Management of the Hypotensive Out-of-Hospital Cardiac Arrest Patient in the Adult Intensive Care Unit.
Journal: European heart journal. Acute cardiovascular care
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41014602
Summary: This review focuses on the critical management of hypotension defined as mean arterial blood pressure less than sixty-five millimeters of mercury in adult intensive care unit patients after out-of-hospital cardiac arrest. It highlights that post-resuscitation hypotension, potentially caused by arrhythmias or mechanical complications, significantly contributes to morbidity and mortality, necessitating precise hemodynamic monitoring and interventions.
Article 2: On the Measurement of the Vortex Formation Time in the Left Ventricle.
Journal: American journal of physiology. Heart and circulatory physiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015431
Summary: This study addresses inconsistencies in measuring vortex formation time, a potential metric for left ventricular performance during diastole, by proposing a new formulation grounded in fluid dynamics. It aims to clarify the measurement challenges and enhance the clinical utility of vortex formation time as an indicator of cardiac filling efficiency.
Article 3: Cigarette Smoking Induces NLRP3 Inflammasome Activation in Atrial Fibrillation Patients.
Journal: American journal of physiology. Heart and circulatory physiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015415
Summary: This research demonstrates that cigarette smoking directly activates the NLRP3 inflammasome, a key inflammatory pathway, in patients with atrial fibrillation. These findings establish a direct molecular link between smoking and the inflammation implicated in the initiation and persistence of atrial fibrillation.
Article 4: Objective assessment of cardiac function using patient-specific biophysical modeling based on cardiovascular MRI combined with catheterization.
Journal: American journal of physiology. Heart and circulatory physiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015406
Summary: This study presents a framework for synthesizing multi-modality data, specifically cardiovascular magnetic resonance imaging and catheterization, into patient-specific biophysical models. This approach facilitates noise filtering and quantifies myocardial contractility, offering objective assessments of cardiac function beyond readily available data metrics.
Article 5: Conventional Tobacco and Electronic Cigarettes Differentially Affect Cardiovascular Health in Male and Female Mice.
Journal: American journal of physiology. Heart and circulatory physiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015405
Summary: This research investigates the differential cardiovascular effects of conventional and electronic cigarettes in male and female mice, particularly when combined with a Western diet. The study evaluates aerosol exposures and their impact on cardiovascular health, comparing the risks of electronic cigarettes to traditional tobacco cigarettes.
Transcript
Today’s date is September 29, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Hemodynamic Monitoring and Management of the Hypotensive Out-of-Hospital Cardiac Arrest Patient in the Adult Intensive Care Unit. This review focuses on the critical management of hypotension defined as mean arterial blood pressure less than sixty-five millimeters of mercury in adult intensive care unit patients after out-of-hospital cardiac arrest. It highlights that post-resuscitation hypotension, potentially caused by arrhythmias or mechanical complications, significantly contributes to morbidity and mortality, necessitating precise hemodynamic monitoring and interventions.
Article number two. On the Measurement of the Vortex Formation Time in the Left Ventricle. This study addresses inconsistencies in measuring vortex formation time, a potential metric for left ventricular performance during diastole, by proposing a new formulation grounded in fluid dynamics. It aims to clarify the measurement challenges and enhance the clinical utility of vortex formation time as an indicator of cardiac filling efficiency.
Article number three. Cigarette Smoking Induces NLRP3 Inflammasome Activation in Atrial Fibrillation Patients. This research demonstrates that cigarette smoking directly activates the NLRP3 inflammasome, a key inflammatory pathway, in patients with atrial fibrillation. These findings establish a direct molecular link between smoking and the inflammation implicated in the initiation and persistence of atrial fibrillation.
Article number four. Objective assessment of cardiac function using patient-specific biophysical modeling based on cardiovascular MRI combined with catheterization. This study presents a framework for synthesizing multi-modality data, specifically cardiovascular magnetic resonance imaging and catheterization, into patient-specific biophysical models. This approach facilitates noise filtering and quantifies myocardial contractility, offering objective assessments of cardiac function beyond readily available data metrics.
Article number five. Conventional Tobacco and Electronic Cigarettes Differentially Affect Cardiovascular Health in Male and Female Mice. This research investigates the differential cardiovascular effects of conventional and electronic cigarettes in male and female mice, particularly when combined with a Western diet. The study evaluates aerosol exposures and their impact on cardiovascular health, comparing the risks of electronic cigarettes to traditional tobacco cigarettes.
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Keywords
Western diet, diastole, hypotension, vortex formation time, fluid dynamics, myocardial contractility, cardiovascular health, cardiovascular imaging, hemodynamic monitoring, arrhythmia, cardiac filling, intensive care unit, biophysical modeling, cigarette smoking, left ventricular function, post-resuscitation care, catheterization, atrial fibrillation, conventional cigarettes, electronic cigarettes, NLRP3 inflammasome, cardiac MRI, inflammation, mice, out-of-hospital cardiac arrest.
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