Welcome to Cardiology Today – Recorded October 19, 2025. This episode summarizes 5 key cardiology studies on topics like cardiogenic shock and drug-eluting stents. Key takeaway: R.B.M.20 Therapy Reverses HeF.pEF Diastolic Dysfunction.
Article Links:
Article 1: Clinical Outcomes Following Percutaneous Coronary Intervention with Drug-Eluting Stents and Drug-Coated Balloons in Lesion with Eruptive Calcified Nodules. (The American journal of cardiology)
Article 2: Deep Dive Rendezvous as a Novel Alternative Technique for Conventional Externalization in Retrograde Chronic Total Occlusion Interventions. (The American journal of cardiology)
Article 3: Comparison of dual- versus triple-targeted drug therapy for patients with left-to-right shunt congenital heart disease-associated pulmonary arterial hypertension. (Cardiology)
Article 4: Cardiogenic Shock in Takotsubo vs. Acute Myocardial Infarction: Insights from The National Readmission Database 2016-2022. (The Canadian journal of cardiology)
Article 5: Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF). (Cardiovascular research)
Full episode page: https://podcast.explainheart.com/podcast/r-b-m-20-therapy-reverses-hef-pef-diastolic-dysfunction-10-19-25/
Featured Articles
Article 1: Clinical Outcomes Following Percutaneous Coronary Intervention with Drug-Eluting Stents and Drug-Coated Balloons in Lesion with Eruptive Calcified Nodules.
Journal: The American journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41109611
Summary: This study investigated clinical outcomes of percutaneous coronary intervention for high-risk eruptive calcified nodules using either drug-eluting stents or drug-coated balloons. Researchers conducted optical coherence tomography-guided P.C.I. in 1,975 patients to gather comparative data on these treatment strategies, which was previously unavailable. This research provides a crucial foundation for understanding the optimal P.C.I. approach for these complex lesions. The findings will help improve patient care by guiding device selection for eruptive calcified nodules.
Article 2: Deep Dive Rendezvous as a Novel Alternative Technique for Conventional Externalization in Retrograde Chronic Total Occlusion Interventions.
Journal: The American journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41109610
Summary: This article introduces and examines the “Deep Dive Rendezvous” technique as an alternative to conventional externalization in retrograde chronic total occlusion percutaneous coronary intervention. The research addresses significant challenges of conventional externalization, such as procedural complexity, increased equipment requirements, and risk of fragile collateral vessel rupture. This innovative technique offers a simpler and potentially safer approach for complex C.T.O.-P.C.I. when antegrade methods are insufficient. The study establishes a valuable new tool for interventional cardiologists, aiming to enhance procedural safety and improve patient outcomes.
Article 3: Comparison of dual- versus triple-targeted drug therapy for patients with left-to-right shunt congenital heart disease-associated pulmonary arterial hypertension.
Journal: Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41105551
Summary: This study compared the efficacy of triple- versus dual-targeted drug therapy in 67 patients with left-to-right shunt congenital heart disease-associated pulmonary arterial hypertension. The research also evaluated treatment outcomes and prognosis in this cohort, further categorizing patients based on potential defect closure. Given the limited evidence on optimal targeted therapy for this complex condition, the study provides crucial data. This investigation advances the understanding of effective management strategies, aiming to improve the long-term prognosis for individuals with congenital heart disease-associated pulmonary arterial hypertension.
Article 4: Cardiogenic Shock in Takotsubo vs. Acute Myocardial Infarction: Insights from The National Readmission Database 2016-2022.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41109669
Summary: Acute Myocardial Infarction: Insights from The National Readmission Database 2016-2022. This study used the Nationwide Readmissions Database from 2016 to 2022 to compare cardiogenic shock in Takotsubo cardiomyopathy versus acute myocardial infarction. Researchers identified hospitalizations for cardiogenic shock, classifying cases as either T.C.-C.S. or A.M.I.-C.S., to analyze demographic features, clinical characteristics, and treatment strategies. This investigation provides critical comparative data on these distinct causes of cardiogenic shock, an area previously understudied for Takotsubo cardiomyopathy. The findings are vital for accurate diagnosis, tailored management, and improving patient outcomes in both severe conditions.
Article 5: Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF).
Journal: Cardiovascular research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41104480
Summary: This study investigated whether R.B.M.20 antisense oligonucleotides (A.S.O.s) could alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure with preserved ejection fraction. Researchers demonstrated that inhibiting R.B.M.20 using A.S.O.s induces the expression of larger titin isoforms, a key determinant of diastolic function. Critically, this intervention successfully alleviated diastolic dysfunction, identifying a novel therapeutic target for heart failure with preserved ejection fraction. This breakthrough provides a promising new strategy for treating this prevalent, deadly, and difficult-to-manage condition.
Transcript
Today’s date is October 19, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Clinical Outcomes Following Percutaneous Coronary Intervention with Drug-Eluting Stents and Drug-Coated Balloons in Lesion with Eruptive Calcified Nodules. This study investigated clinical outcomes of percutaneous coronary intervention for high-risk eruptive calcified nodules using either drug-eluting stents or drug-coated balloons. Researchers conducted optical coherence tomography-guided P.C.I. in 1,975 patients to gather comparative data on these treatment strategies, which was previously unavailable. This research provides a crucial foundation for understanding the optimal P.C.I. approach for these complex lesions. The findings will help improve patient care by guiding device selection for eruptive calcified nodules.
Article number two. Deep Dive Rendezvous as a Novel Alternative Technique for Conventional Externalization in Retrograde Chronic Total Occlusion Interventions. This article introduces and examines the “Deep Dive Rendezvous” technique as an alternative to conventional externalization in retrograde chronic total occlusion percutaneous coronary intervention. The research addresses significant challenges of conventional externalization, such as procedural complexity, increased equipment requirements, and risk of fragile collateral vessel rupture. This innovative technique offers a simpler and potentially safer approach for complex C.T.O.-P.C.I. when antegrade methods are insufficient. The study establishes a valuable new tool for interventional cardiologists, aiming to enhance procedural safety and improve patient outcomes.
Article number three. Comparison of dual- versus triple-targeted drug therapy for patients with left-to-right shunt congenital heart disease-associated pulmonary arterial hypertension. This study compared the efficacy of triple- versus dual-targeted drug therapy in 67 patients with left-to-right shunt congenital heart disease-associated pulmonary arterial hypertension. The research also evaluated treatment outcomes and prognosis in this cohort, further categorizing patients based on potential defect closure. Given the limited evidence on optimal targeted therapy for this complex condition, the study provides crucial data. This investigation advances the understanding of effective management strategies, aiming to improve the long-term prognosis for individuals with congenital heart disease-associated pulmonary arterial hypertension.
Article number four. Cardiogenic Shock in Takotsubo vs. Acute Myocardial Infarction: Insights from The National Readmission Database 2016-2022. This study used the Nationwide Readmissions Database from 2016 to 2022 to compare cardiogenic shock in Takotsubo cardiomyopathy versus acute myocardial infarction. Researchers identified hospitalizations for cardiogenic shock, classifying cases as either T.C.-C.S. or A.M.I.-C.S., to analyze demographic features, clinical characteristics, and treatment strategies. This investigation provides critical comparative data on these distinct causes of cardiogenic shock, an area previously understudied for Takotsubo cardiomyopathy. The findings are vital for accurate diagnosis, tailored management, and improving patient outcomes in both severe conditions.
Article number five. Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF). This study investigated whether R.B.M.20 antisense oligonucleotides (A.S.O.s) could alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure with preserved ejection fraction. Researchers demonstrated that inhibiting R.B.M.20 using A.S.O.s induces the expression of larger titin isoforms, a key determinant of diastolic function. Critically, this intervention successfully alleviated diastolic dysfunction, identifying a novel therapeutic target for heart failure with preserved ejection fraction. This breakthrough provides a promising new strategy for treating this prevalent, deadly, and difficult-to-manage condition.
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Keywords
cardiogenic shock, drug-eluting stents, pulmonary arterial hypertension, antisense oligonucleotides, percutaneous coronary intervention, left-to-right shunt, clinical outcomes, drug-coated balloons, Takotsubo cardiomyopathy, R.B.M.20, diastolic dysfunction, Nationwide Readmissions Database, heart failure with preserved ejection fraction, chronic total occlusion, conventional externalization, titin, Deep Dive Rendezvous, congenital heart disease, optical coherence tomography, acute myocardial infarction, eruptive calcified nodules, retrograde approach, targeted drug therapy, prognosis.
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