Welcome to Cardiology Today – Recorded December 01, 2025. This episode summarizes 5 key cardiology studies on topics like lipid transport and short-term outcomes. Key takeaway: PE Calculator Predicts Short-Term Outcomes.
Article Links:
Article 1: Deletion of METTL14, a key methylation regulator, attenuates vascular ageing. (European heart journal)
Article 2: Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response. (European heart journal)
Article 3: The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. (European heart journal)
Article 4: Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes. (European heart journal)
Article 5: Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages. (European heart journal)
Full episode page: https://podcast.explainheart.com/podcast/pe-calculator-predicts-short-term-outcomes-12-01-25/
Featured Articles
Article 1: Deletion of METTL14, a key methylation regulator, attenuates vascular ageing.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40758401
Summary: Deletion of methyltransferase-like protein 14 (METTL14) was found to attenuate vascular aging. This suggests that METTL14 plays a role in promoting vascular aging, possibly by influencing inflammation. Modulating METTL14 activity could therefore represent a therapeutic strategy to combat age-related vascular diseases.
Article 2: Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40720766
Summary: This study found that excessive glycosylation drives the formation of thoracic aortic aneurysms and dissections (TAADs) through activation of the integrated stress response. The hexosamine biosynthetic pathway was identified as a key contributor to this process in both sporadic and genetic forms of thoracic aortic aneurysm. This mechanistic insight suggests that targeting the hexosamine biosynthetic pathway could offer a therapeutic approach for preventing or treating thoracic aortic aneurysms and related conditions such as Marfan syndrome.
Article 3: The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40709729
Summary: Kinesin family member 13B (KIF13B), a macrophage-derived motor protein, was found to enhance MERTK-mediated efferocytosis. This enhancement of efferocytosis, which is the clearance of apoptotic cells, resulted in the prevention of atherosclerosis in mice. The data suggests that KIF13B plays a protective role against atherosclerosis by improving cellular waste removal, indicating its potential as a therapeutic target.
Article 4: Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40391731
Summary: A multimarker prognostic calculator was developed to predict short-term outcomes in patients with acute pulmonary embolism (P. E.). This calculator estimates the absolute risk of key outcomes for individual patients, utilizing variables from the simplified Pulmonary Embolism Severity Index and other markers. The study validated the calculator’s performance and compared it to the established European Society of Cardiology (E. S. C.) model for risk stratification in acute pulmonary embolism, providing a tool for targeted interventions.
Article 5: Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40259807
Summary: Nuclear receptor Dosage-sensitive sex reversal, adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (Dax1) was found to promote atherosclerosis. This pro-atherogenic effect occurs through the inhibition of lipid transport and suppression of autophagy within macrophages. The study identified Dax1 levels in human atherosclerotic arteries, suggesting Dax1 as a potential pharmacological target for preventing atherosclerosis.
Transcript
Today’s date is December 01, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Deletion of METTL14, a key methylation regulator, attenuates vascular ageing. Deletion of methyltransferase-like protein 14 (METTL14) was found to attenuate vascular aging. This suggests that METTL14 plays a role in promoting vascular aging, possibly by influencing inflammation. Modulating METTL14 activity could therefore represent a therapeutic strategy to combat age-related vascular diseases.
Article number two. Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response. This study found that excessive glycosylation drives the formation of thoracic aortic aneurysms and dissections (TAADs) through activation of the integrated stress response. The hexosamine biosynthetic pathway was identified as a key contributor to this process in both sporadic and genetic forms of thoracic aortic aneurysm. This mechanistic insight suggests that targeting the hexosamine biosynthetic pathway could offer a therapeutic approach for preventing or treating thoracic aortic aneurysms and related conditions such as Marfan syndrome.
Article number three. The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. Kinesin family member 13B (KIF13B), a macrophage-derived motor protein, was found to enhance MERTK-mediated efferocytosis. This enhancement of efferocytosis, which is the clearance of apoptotic cells, resulted in the prevention of atherosclerosis in mice. The data suggests that KIF13B plays a protective role against atherosclerosis by improving cellular waste removal, indicating its potential as a therapeutic target.
Article number four. Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes. A multimarker prognostic calculator was developed to predict short-term outcomes in patients with acute pulmonary embolism (P. E.). This calculator estimates the absolute risk of key outcomes for individual patients, utilizing variables from the simplified Pulmonary Embolism Severity Index and other markers. The study validated the calculator’s performance and compared it to the established European Society of Cardiology (E. S. C.) model for risk stratification in acute pulmonary embolism, providing a tool for targeted interventions.
Article number five. Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages. Nuclear receptor Dosage-sensitive sex reversal, adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (Dax1) was found to promote atherosclerosis. This pro-atherogenic effect occurs through the inhibition of lipid transport and suppression of autophagy within macrophages. The study identified Dax1 levels in human atherosclerotic arteries, suggesting Dax1 as a potential pharmacological target for preventing atherosclerosis.
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Keywords
lipid transport, short-term outcomes, Dax1, hexosamine biosynthetic pathway, vascular aging, prognostic calculator, inflammation, risk stratification, nuclear receptor, pulmonary embolism, Pulmonary Embolism Severity Index, autophagy, thoracic aortic aneurysm, methylation, integrated stress response, MERTK, efferocytosis, METTL14, atherosclerosis, Marfan syndrome, glycosylation, macrophages, KIF13B.
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The post PE Calculator Predicts Short-Term Outcomes 12/01/25 first appeared on Cardiology Today.