Welcome to Cardiology Today – Recorded October 22, 2025. This episode summarizes 5 key cardiology studies on topics like aortic insufficiency and Korean National Health Insurance Service. Key takeaway: Off-Label Device Expands PDA Closure Options.
Article Links:
Article 1: Short-Term Effects of Personal-Level Environmental Temperature on Ambulatory Blood Pressure in Patients With Hypertension: A Multicity Panel Study. (Journal of the American Heart Association)
Article 2: Occupational and Nonoccupational Physical Activity and Their Association With All-Cause, Cardiovascular, and Cancer Mortality in US Adults: A Prospective Cohort Study from the NHANES 2007 to 2018. (Journal of the American Heart Association)
Article 3: Validation of the Hemodynamic Classification System for Hemodynamic-Related Events in Patients With Durable Left Ventricular Assist Devices. (Journal of the American Heart Association)
Article 4: Antibiotic Exposure and Cardiovascular Disease Risk: A Nationwide Cohort Study. (Journal of the American Heart Association)
Article 5: Off-Label Use of the Multifunctional Occluder for Transcatheter Patent Ductus Arteriosus Closure: An International Experience. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/off-label-device-expands-pda-closure-options-10-22-25/
Featured Articles
Article 1: Short-Term Effects of Personal-Level Environmental Temperature on Ambulatory Blood Pressure in Patients With Hypertension: A Multicity Panel Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41120825
Summary: This multicity panel study aimed to clarify the short-term effects of personal-level environmental temperature on ambulatory blood pressure in 277 hypertensive patients across four Chinese cities. Researchers utilized continuous personal portable monitors to record both environmental temperature and ambulatory blood pressure. This robust methodology establishes a significant framework for understanding how individual thermal exposure impacts blood pressure management, which is crucial for optimizing cardiovascular health strategies in hypertensive populations.
Article 2: Occupational and Nonoccupational Physical Activity and Their Association With All-Cause, Cardiovascular, and Cancer Mortality in US Adults: A Prospective Cohort Study from the NHANES 2007 to 2018.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41120824
Summary: 2007 to 2018. This prospective cohort study, utilizing data from the National Health and Nutrition Examination Survey (N.H.A.N.E.S.) between 2007 and 2018, sought to determine if achieving physical activity guidelines through occupational, nonoccupational, or combined activity differentially impacts all-cause, cardiovascular, and cancer mortality in U.S. adults. By meticulously observing participants aged 18 years or older and acquiring mortality data through the National Death Index, this research establishes a vital framework. This study is crucial for providing clarity on the specific health benefits associated with distinct types of physical activity, informing public health guidelines and personalized recommendations for improving longevity and reducing disease burden.
Article 3: Validation of the Hemodynamic Classification System for Hemodynamic-Related Events in Patients With Durable Left Ventricular Assist Devices.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41120820
Summary: This study aimed to validate the new durable left ventricular assist device (d.L.V.A.D.) Hemodynamic Classification System designed for hemodynamic-related events, specifically right heart failure and aortic insufficiency. Researchers adjudicated, staged, and phenotyped these events at six months post-d.L.V.A.D. implantation, with the primary outcome being a composite of heart failure hospitalization or cardiac mortality. The validation of this classification system is critical for standardizing the assessment and management of common and serious complications in patients with durable left ventricular assist devices, which can significantly improve patient stratification and therapeutic guidance.
Article 4: Antibiotic Exposure and Cardiovascular Disease Risk: A Nationwide Cohort Study.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41120818
Summary: This nationwide retrospective cohort study, utilizing data from the Korean National Health Insurance Service database, meticulously evaluated the potential association between long-term antibiotic exposure and cardiovascular disease (C.V.D.) risk in over two million individuals. The research aimed to provide essential epidemiological evidence to clarify this relationship, given that antibiotic use can alter gut microbiota, which is hypothesized to impact cardiovascular health. Establishing this association is critically important for understanding potential long-term risks associated with antibiotic use and could inform prescribing practices to mitigate future cardiovascular disease burden.
Article 5: Off-Label Use of the Multifunctional Occluder for Transcatheter Patent Ductus Arteriosus Closure: An International Experience.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41120817
Summary: This international retrospective analysis investigated the feasibility, efficacy, and safety of using a multifunctional occluder off-label for transcatheter patent ductus arteriosus (P.D.A.) closure, especially in challenging anatomical cases or small patients. The study meticulously compiled data from 77 procedures performed across 14 pediatric cardiology centers in five countries between 2018 and 2025. This research significantly advances the understanding of alternative treatment options for complex patent ductus arteriosus, potentially expanding therapeutic approaches and improving outcomes in vulnerable pediatric populations.
Transcript
Today’s date is October 22, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Short-Term Effects of Personal-Level Environmental Temperature on Ambulatory Blood Pressure in Patients With Hypertension: A Multicity Panel Study. This multicity panel study aimed to clarify the short-term effects of personal-level environmental temperature on ambulatory blood pressure in 277 hypertensive patients across four Chinese cities. Researchers utilized continuous personal portable monitors to record both environmental temperature and ambulatory blood pressure. This robust methodology establishes a significant framework for understanding how individual thermal exposure impacts blood pressure management, which is crucial for optimizing cardiovascular health strategies in hypertensive populations.
Article number two. Occupational and Nonoccupational Physical Activity and Their Association With All-Cause, Cardiovascular, and Cancer Mortality in US Adults: A Prospective Cohort Study from the N.H.A.N.E.S. 2007 to 2018. This prospective cohort study, utilizing data from the National Health and Nutrition Examination Survey (N.H.A.N.E.S.) between 2007 and 2018, sought to determine if achieving physical activity guidelines through occupational, nonoccupational, or combined activity differentially impacts all-cause, cardiovascular, and cancer mortality in U.S. adults. By meticulously observing participants aged 18 years or older and acquiring mortality data through the National Death Index, this research establishes a vital framework. This study is crucial for providing clarity on the specific health benefits associated with distinct types of physical activity, informing public health guidelines and personalized recommendations for improving longevity and reducing disease burden.
Article number three. Validation of the Hemodynamic Classification System for Hemodynamic-Related Events in Patients With Durable Left Ventricular Assist Devices. This study aimed to validate the new durable left ventricular assist device (d.L.V.A.D.) Hemodynamic Classification System designed for hemodynamic-related events, specifically right heart failure and aortic insufficiency. Researchers adjudicated, staged, and phenotyped these events at six months post-d.L.V.A.D. implantation, with the primary outcome being a composite of heart failure hospitalization or cardiac mortality. The validation of this classification system is critical for standardizing the assessment and management of common and serious complications in patients with durable left ventricular assist devices, which can significantly improve patient stratification and therapeutic guidance.
Article number four. Antibiotic Exposure and Cardiovascular Disease Risk: A Nationwide Cohort Study. This nationwide retrospective cohort study, utilizing data from the Korean National Health Insurance Service database, meticulously evaluated the potential association between long-term antibiotic exposure and cardiovascular disease (C.V.D.) risk in over two million individuals. The research aimed to provide essential epidemiological evidence to clarify this relationship, given that antibiotic use can alter gut microbiota, which is hypothesized to impact cardiovascular health. Establishing this association is critically important for understanding potential long-term risks associated with antibiotic use and could inform prescribing practices to mitigate future cardiovascular disease burden.
Article number five. Off-Label Use of the Multifunctional Occluder for Transcatheter Patent Ductus Arteriosus Closure: An International Experience. This international retrospective analysis investigated the feasibility, efficacy, and safety of using a multifunctional occluder off-label for transcatheter patent ductus arteriosus (P.D.A.) closure, especially in challenging anatomical cases or small patients. The study meticulously compiled data from 77 procedures performed across 14 pediatric cardiology centers in five countries between 2018 and 2025. This research significantly advances the understanding of alternative treatment options for complex patent ductus arteriosus, potentially expanding therapeutic approaches and improving outcomes in vulnerable pediatric populations.
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Keywords
aortic insufficiency, Korean National Health Insurance Service, durable left ventricular assist device, off-label use, multifunctional occluder, ambulatory blood pressure, transcatheter patent ductus arteriosus closure, cardiac mortality, nationwide cohort study, National Health and Nutrition Examination Survey, physical activity, right heart failure, pediatric cardiology, cardiovascular mortality, cardiovascular disease risk, P.D.A., gut microbiota, environmental temperature, occupational activity, all-cause mortality, cancer mortality, d.L.V.A.D., hemodynamic classification system, hypertension, antibiotic exposure, congenital heart disease, heart failure hospitalization, nonoccupational activity.
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