Welcome to Cardiology Today – Recorded October 20, 2025. This episode summarizes 5 key cardiology studies on topics like Defibrillation lead and echocardiography. Key takeaway: New Defib Lead for LBB Pacing.
Article Links:
Article 1: The Predictive Power of Left Atrial Reservoir Strain for Long-Term Atrial Fibrillation in The Atherosclerosis Risk in Communities (ARIC) Study. (Heart rhythm)
Article 2: Safety and performance of a novel defibrillation lead for left bundle branch area placement: primary results of the LEADR LBBAP clinical trial. (Heart rhythm)
Article 3: Optimization of Pacing for Patients Receiving Ineffective Cardiac Resynchronization Therapy. (Heart rhythm)
Article 4: Clinical and Prognostic Implications of Precipitating Factors in Patients with Spontaneous Coronary Artery Dissection. (The American journal of cardiology)
Article 5: Incidence and Predictors of Atrial Fibrillation After Cavotricuspid Isthmus Ablation for Typical Atrial Flutter. (The American journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/new-defib-lead-for-lbb-pacing-10-20-25/
Featured Articles
Article 1: The Predictive Power of Left Atrial Reservoir Strain for Long-Term Atrial Fibrillation in The Atherosclerosis Risk in Communities (ARIC) Study.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41110530
Summary: This study aimed to assess the standalone predictive power of Left Atrial Reservoir Strain (L.A.R.S.) measures obtained from two-dimensional echocardiograms for long-term Atrial Fibrillation (A.fib) prediction over 5 and 10 years. Researchers analyzed data from 5,442 older adults (median age 74) from the Atherosclerosis Risk in Communities (A.R.I.C.) study who had no prior Atrial Fibrillation. By investigating L.A.R.S., the study sought to determine if this measure could independently predict future Atrial Fibrillation development. Establishing such a predictive value would enable earlier identification of individuals at high risk for Atrial Fibrillation, facilitating timely monitoring and intervention strategies.
Article 2: Safety and performance of a novel defibrillation lead for left bundle branch area placement: primary results of the LEADR LBBAP clinical trial.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41110529
Summary: The L.E.A.D.R. L.B.B.A.P. clinical trial investigated the defibrillation efficacy at implant and the safety profile of the OmniaSecure lead when used for Left Bundle Branch Area Pacing (L.B.B.A.P.). This study aimed to determine if this lead, previously successful in Right Ventricular placement, could serve as a viable option for physiological pacing in patients requiring an implantable cardioverter-defibrillator (I.C.D.). By enrolling patients indicated for I.C.D. placement globally, the trial sought to establish the lead’s performance. Successful integration of Left Bundle Branch Area Pacing with defibrillation capabilities could offer a significant advancement in cardiac rhythm management for these patients.
Article 3: Optimization of Pacing for Patients Receiving Ineffective Cardiac Resynchronization Therapy.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41110528
Summary: This study investigated the characteristics and efficacy of pacing optimization strategies for patients experiencing a high percentage of ineffective Cardiac Resynchronization Therapy (C.R.T.). High ineffective C.R.T. pacing ( percenti-C.R.T.) has been linked to poor patient prognosis, yet optimal follow-up settings for these individuals remain unclear. Researchers assessed 225 consecutive patients between 2018 and 2024 using the EffectivC.R.T. system from Medtronic Inc. The goal was to establish effective methods for optimizing C.R.T. delivery, potentially improving outcomes for patients who are not adequately responding to standard therapy.
Article 4: Clinical and Prognostic Implications of Precipitating Factors in Patients with Spontaneous Coronary Artery Dissection.
Journal: The American journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41110817
Summary: This study aimed to evaluate the clinical and prognostic relevance of precipitating factors in patients presenting with Spontaneous Coronary Artery Dissection (S.C.A.D.), a rare cause of acute coronary syndrome (A.C.S.). While S.C.A.D. has traditionally been linked to pregnancy, it is increasingly associated with emotional and physical stressors. The prospective Spanish S.C.A.D. Registry (R.N.-D.C.E.) provided data from 388 patients across 34 centers since 2015, with coronary angiograms reviewed. By clarifying the impact of these factors, the research contributes to better understanding S.C.A.D. etiology and improving risk stratification and patient management.
Article 5: Incidence and Predictors of Atrial Fibrillation After Cavotricuspid Isthmus Ablation for Typical Atrial Flutter.
Journal: The American journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41110816
Summary: This study aimed to investigate the incidence and identify specific predictors of new-onset Atrial Fibrillation (A.fib) following Cavotricuspid Isthmus (C.T.I.) ablation, a highly effective treatment for typical Atrial Flutter (A.F.L.). While C.T.I. ablation successfully treats Atrial Flutter, the subsequent emergence of Atrial Fibrillation is a known clinical concern with limited data on its predictors. Researchers included patients who underwent C.T.I. ablation between 2016 and 2022, assessing baseline variables such as Left Atrial Volume Index (L.A.V.I.) and cardiac comorbidities. Identifying these predictors could significantly improve patient selection, risk assessment, and post-procedural management to mitigate the risk of developing new-onset Atrial Fibrillation.
Transcript
Today’s date is October 20, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. The Predictive Power of Left Atrial Reservoir Strain for Long-Term Atrial Fibrillation in The Atherosclerosis Risk in Communities (ARIC) Study. This study aimed to assess the standalone predictive power of Left Atrial Reservoir Strain (L.A.R.S.) measures obtained from two-dimensional echocardiograms for long-term Atrial Fibrillation (A.fib) prediction over 5 and 10 years. Researchers analyzed data from 5,442 older adults (median age 74) from the Atherosclerosis Risk in Communities (A.R.I.C.) study who had no prior Atrial Fibrillation. By investigating L.A.R.S., the study sought to determine if this measure could independently predict future Atrial Fibrillation development. Establishing such a predictive value would enable earlier identification of individuals at high risk for Atrial Fibrillation, facilitating timely monitoring and intervention strategies.
Article number two. Safety and performance of a novel defibrillation lead for left bundle branch area placement: primary results of the LEADR LBBAP clinical trial. The L.E.A.D.R. L.B.B.A.P. clinical trial investigated the defibrillation efficacy at implant and the safety profile of the OmniaSecure lead when used for Left Bundle Branch Area Pacing (L.B.B.A.P.). This study aimed to determine if this lead, previously successful in Right Ventricular placement, could serve as a viable option for physiological pacing in patients requiring an implantable cardioverter-defibrillator (I.C.D.). By enrolling patients indicated for I.C.D. placement globally, the trial sought to establish the lead’s performance. Successful integration of Left Bundle Branch Area Pacing with defibrillation capabilities could offer a significant advancement in cardiac rhythm management for these patients.
Article number three. Optimization of Pacing for Patients Receiving Ineffective Cardiac Resynchronization Therapy. This study investigated the characteristics and efficacy of pacing optimization strategies for patients experiencing a high percentage of ineffective Cardiac Resynchronization Therapy (C.R.T.). High ineffective C.R.T. pacing ( percenti-C.R.T.) has been linked to poor patient prognosis, yet optimal follow-up settings for these individuals remain unclear. Researchers assessed 225 consecutive patients between 2018 and 2024 using the EffectivC.R.T. system from Medtronic Inc. The goal was to establish effective methods for optimizing C.R.T. delivery, potentially improving outcomes for patients who are not adequately responding to standard therapy.
Article number four. Clinical and Prognostic Implications of Precipitating Factors in Patients with Spontaneous Coronary Artery Dissection. This study aimed to evaluate the clinical and prognostic relevance of precipitating factors in patients presenting with Spontaneous Coronary Artery Dissection (S.C.A.D.), a rare cause of acute coronary syndrome (A.C.S.). While S.C.A.D. has traditionally been linked to pregnancy, it is increasingly associated with emotional and physical stressors. The prospective Spanish S.C.A.D. Registry (R.N.-D.C.E.) provided data from 388 patients across 34 centers since 2015, with coronary angiograms reviewed. By clarifying the impact of these factors, the research contributes to better understanding S.C.A.D. etiology and improving risk stratification and patient management.
Article number five. Incidence and Predictors of Atrial Fibrillation After Cavotricuspid Isthmus Ablation for Typical Atrial Flutter. This study aimed to investigate the incidence and identify specific predictors of new-onset Atrial Fibrillation (A.fib) following Cavotricuspid Isthmus (C.T.I.) ablation, a highly effective treatment for typical Atrial Flutter (A.F.L.). While C.T.I. ablation successfully treats Atrial Flutter, the subsequent emergence of Atrial Fibrillation is a known clinical concern with limited data on its predictors. Researchers included patients who underwent C.T.I. ablation between 2016 and 2022, assessing baseline variables such as Left Atrial Volume Index (L.A.V.I.) and cardiac comorbidities. Identifying these predictors could significantly improve patient selection, risk assessment, and post-procedural management to mitigate the risk of developing new-onset Atrial Fibrillation.
Thank you for listening. Don’t forget to subscribe.
Keywords
Defibrillation lead, echocardiography, post-ablation complications, implantable cardioverter-defibrillator, acute coronary syndrome, Left Bundle Branch Area Pacing, EffectivC.R.T., pacing optimization, S.C.A.D. Registry, long-term prediction, Left Atrial Reservoir Strain, Cavotricuspid Isthmus ablation, prognosis, Atrial Flutter, precipitating factors, Atrial Fibrillation, lead safety, Atherosclerosis Risk in Communities study, Left Atrial Volume Index, Cardiac Resynchronization Therapy, LEADR LBBAP clinical trial, new-onset Atrial Fibrillation, Spontaneous Coronary Artery Dissection, ineffective pacing.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • Follow
The post New Defib Lead for LBB Pacing 10/20/25 first appeared on Cardiology Today.