Welcome to Cardiology Today – Recorded October 21, 2025. This episode summarizes 5 key cardiology studies on topics like Graves’ disease and adolescents. Key takeaway: Metabolomics Guides BP Post-Bariatric Surgery.
Article Links:
Article 1: Ventricular arrhythmias during exercise in patients with mitral valve prolapse. (Heart (British Cardiac Society))
Article 2: Impact of Disease Duration on Left Atrial Function in Patients with Graves’ Disease. (Cardiology)
Article 3: Plasma Metabolomic and Proteomic Signatures of Blood Pressure Management After Bariatric Surgery Among Adolescents. (Hypertension (Dallas, Tex. : 1979))
Article 4: Effect of Parity and Previous Preeclampsia on Maternal Hemodynamics. (Hypertension (Dallas, Tex. : 1979))
Article 5: Role of Ethnicity and Sex in Hypertension-Mediated Organ Damage in a Dual-Ethnic Cohort of Individuals With Hypertension. (Hypertension (Dallas, Tex. : 1979))
Full episode page: https://podcast.explainheart.com/podcast/metabolomics-guides-bp-post-bariatric-surgery-10-21-25/
Featured Articles
Article 1: Ventricular arrhythmias during exercise in patients with mitral valve prolapse.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41115769
Summary: This multicenter study assessed the occurrence and severity of ventricular arrhythmias (V.A.) during exercise tests in 375 patients with mitral valve prolapse (M.V.P.). The research also explored the association between V.A. during exercise and the subsequent incidence of arrhythmic events during follow-up. This study establishes a clearer understanding of exercise-induced arrhythmias in M.V.P. patients, which is critical for their risk stratification and clinical management.
Article 2: Impact of Disease Duration on Left Atrial Function in Patients with Graves’ Disease.
Journal: Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41115099
Summary: This cross-sectional study investigated the relationship between the duration of Graves’ disease and myocardial deformation parameters, specifically focusing on left atrial (L.A.) strain and left ventricular global longitudinal strain (L.V.-G.L.S.). Comprehensive echocardiographic assessment was performed on 90 patients with Graves’ disease, with disease duration categorized as short or long. The findings provide important insights into how the progression of Graves’ disease influences cardiac function, underscoring the potential for duration-dependent myocardial alterations. These results highlight the importance of timely intervention to preserve cardiac mechanics in patients with Graves’ disease.
Article 3: Plasma Metabolomic and Proteomic Signatures of Blood Pressure Management After Bariatric Surgery Among Adolescents.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41111440
Summary: This study utilized metabolomics and proteomics to identify preoperative plasma profiles that predict long-term elevated blood pressure changes after bariatric surgery in adolescents. Researchers analyzed 108 participants from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-L.A.B.S.) study, employing untargeted metabolomics via liquid chromatography-mass spectrometry and proteomics via tandem mass tag mass spectrometry. This research successfully identified specific molecular signatures that can better predict blood pressure outcomes compared to traditional risk factors. These findings advance personalized medicine by offering potential biomarkers for optimizing blood pressure management following bariatric surgery.
Article 4: Effect of Parity and Previous Preeclampsia on Maternal Hemodynamics.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41111413
Summary: This prospective longitudinal study examined the impact of parity and a history of preeclampsia on maternal hemodynamic profiles throughout pregnancy. Transthoracic echocardiography was used to assess hemodynamics at various gestational stages (12-15, 20-24, and 30-37 weeks) in groups of nulliparous women, parous women without previous preeclampsia, and parous women with previous preeclampsia. The study successfully delineates distinct longitudinal hemodynamic alterations linked to both parity and prior preeclampsia. This provides crucial information for understanding cardiovascular adaptations in pregnancy and for targeted monitoring in women at higher obstetric risk.
Article 5: Role of Ethnicity and Sex in Hypertension-Mediated Organ Damage in a Dual-Ethnic Cohort of Individuals With Hypertension.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41111403
Summary: This study investigated the combined influence of sex and ethnicity on vascular and renal hypertension-mediated organ damage (H.M.O.D.) in a dual-ethnic cohort of individuals with primary hypertension. Furthermore, the researchers explored the association of these disparities with the activation of the renin-angiotensin-aldosterone system, particularly aldosterone levels. This research reveals specific intersections of sex and ethnicity in the manifestation of H.M.O.D., providing a more nuanced understanding of risk factors. The findings suggest the importance of considering these demographic and hormonal factors for tailored hypertension management strategies.
Transcript
Today’s date is October 21, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Ventricular arrhythmias during exercise in patients with mitral valve prolapse. This multicenter study assessed the occurrence and severity of ventricular arrhythmias (V.A.) during exercise tests in 375 patients with mitral valve prolapse (M.V.P.). The research also explored the association between V.A. during exercise and the subsequent incidence of arrhythmic events during follow-up. This study establishes a clearer understanding of exercise-induced arrhythmias in M.V.P. patients, which is critical for their risk stratification and clinical management.
Article number two. Impact of Disease Duration on Left Atrial Function in Patients with Graves’ Disease. This cross-sectional study investigated the relationship between the duration of Graves’ disease and myocardial deformation parameters, specifically focusing on left atrial (L.A.) strain and left ventricular global longitudinal strain (L.V.-G.L.S.). Comprehensive echocardiographic assessment was performed on 90 patients with Graves’ disease, with disease duration categorized as short or long. The findings provide important insights into how the progression of Graves’ disease influences cardiac function, underscoring the potential for duration-dependent myocardial alterations. These results highlight the importance of timely intervention to preserve cardiac mechanics in patients with Graves’ disease.
Article number three. Plasma Metabolomic and Proteomic Signatures of Blood Pressure Management After Bariatric Surgery Among Adolescents. This study utilized metabolomics and proteomics to identify preoperative plasma profiles that predict long-term elevated blood pressure changes after bariatric surgery in adolescents. Researchers analyzed 108 participants from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-L.A.B.S.) study, employing untargeted metabolomics via liquid chromatography-mass spectrometry and proteomics via tandem mass tag mass spectrometry. This research successfully identified specific molecular signatures that can better predict blood pressure outcomes compared to traditional risk factors. These findings advance personalized medicine by offering potential biomarkers for optimizing blood pressure management following bariatric surgery.
Article number four. Effect of Parity and Previous Preeclampsia on Maternal Hemodynamics. This prospective longitudinal study examined the impact of parity and a history of preeclampsia on maternal hemodynamic profiles throughout pregnancy. Transthoracic echocardiography was used to assess hemodynamics at various gestational stages (12-15, 20-24, and 30-37 weeks) in groups of nulliparous women, parous women without previous preeclampsia, and parous women with previous preeclampsia. The study successfully delineates distinct longitudinal hemodynamic alterations linked to both parity and prior preeclampsia. This provides crucial information for understanding cardiovascular adaptations in pregnancy and for targeted monitoring in women at higher obstetric risk.
Article number five. Role of Ethnicity and Sex in Hypertension-Mediated Organ Damage in a Dual-Ethnic Cohort of Individuals With Hypertension. This study investigated the combined influence of sex and ethnicity on vascular and renal hypertension-mediated organ damage (H.M.O.D.) in a dual-ethnic cohort of individuals with primary hypertension. Furthermore, the researchers explored the association of these disparities with the activation of the renin-angiotensin-aldosterone system, particularly aldosterone levels. This research reveals specific intersections of sex and ethnicity in the manifestation of H.M.O.D., providing a more nuanced understanding of risk factors. The findings suggest the importance of considering these demographic and hormonal factors for tailored hypertension management strategies.
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Keywords
Graves’ disease, adolescents, sex, preeclampsia, maternal hemodynamics, pregnancy, ventricular arrhythmias, left ventricular global longitudinal strain, left atrial function, blood pressure management, echocardiography, risk stratification, aldosterone, arrhythmic events, metabolomics, renin-angiotensin-aldosterone system, exercise testing, ethnicity, mitral valve prolapse, proteomics, myocardial deformation, hypertension-mediated organ damage, parity, bariatric surgery, transthoracic echocardiography.
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