What is a "Safe" Gluten Dose? Gluten Threshold Study Results with Gastroenterologist and Director of the Coeliac Disease and Immune Health Research Program at Wesley Research Institute, Dr James Daveson

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A Gluten Free Podcast
Episode 242

My guest on today’s episode is Gastroenterologist and Director of the Coeliac Disease and Immune Health Research Program at Wesley Research Institute, Dr James Daveson. We’ll talk about the Gluten Threshold Study results, how these results could inform international gluten free standards and the need for follow up larger scale studies.

What we’ll cover:
* Aim of the study and what prompted it
* Using Interleukin 2 to measure immune response in participants
* How the Interleukin 2 test was used as a biomarker in this specific trial
* Exploring the question of inadvertent gluten ingestion in causing damage to villi in people with coeliac disease
* Carlo Cattassi’s study in 2007 looking at the minimum amount of gluten causing an autoimmune response
* James and his team looking at what is happening for people with coeliac disease consuming 10 mgs of gluten and under
* The hawthorn effect
* Specifics of the trial and how the study was run
* Dropping the dose of gluten to see where the autoimmune response was occurring at lowering levels
* Findings from the study
* How the results could possibly change labelling and ‘gluten free’ standards and guidelines not only in Australia but worldwide
* Codex Alimentarius food labelling laws
* Shortcomings from this trial
* The potential heterogeneity of coeliac disease (various scales of severity of the disease)
* Eliciting dose of gluten for people with coeliac disease
* Varying symptoms of the participants throughout the Gluten Threshold study before and after the gluten challenge
* Mistakes and surprises in the Gluten Threshold Study
* Symptom scores
* Anticipatory nausea and priming
* The possibility of the immune system being primed before the ingestion of gluten for people with coeliac disease
* The trauma of living with an autoimmune disease or other IBD conditions
* Possible follow up studies from The Gluten Threshold Study
* How this study could be used to a more universal approach to the ppm of gluten
* Digestive Diseases Week in Chicago and how the response from the Gluten Threshold Study
* The interest in novel therapeutics for people with coeliac disease to help people’s guts alongside a gluten free diet
* Enzymes that claim to break down inadvertent gluten ingestion for people with coeliac disease
* Information on how to read the results of the Gluten Threshold Study, participate or help fund future studies and follow Wesley Research Institute on socials

Links
Gluten Threshold Study Results
Wesley Research Institute: Coeliac Disease and Immune Health
Follow Wesley Research Institute on Instagram and Facebook
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This podcast reflects personal experiences and is not medical advice. Please consult a qualified healthcare professional for individual guidance. 

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