Kyle Shanahan previews 49ers' Week 3 matchup vs. Cardinals, Mykel Williams’ versatility on defense
20 September 2025

Kyle Shanahan previews 49ers' Week 3 matchup vs. Cardinals, Mykel Williams’ versatility on defense

49ers Talk: A San Francisco 49ers Podcast

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Matt Maiocco speaks with 49ers coach Kyle Shanahan about their Week 3 matchup vs. the Arizona Cardinals and discuss how Luke Farrell and Jake Tonges have stepped up after injuries to George Kittle and Kyle Juszczyk. Also Greg Papa joins Matt to breaks down how 49ers’ improved speed on defense can contain Kyler Murray.

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(6:19) Kyle Shanahan dissects Mac Jones’ Week 2 performance vs. Saints
(10:08) Shanahan shares how Christian McCaffrey is 49ers’ consistent weapon
(12:10) Shanahan impressed with how Luke Farrell and Jake Tonges have stepped up
(14:14) Shanahan discusses Mykel Williams’ versatility in pass game and third down
(18:12) What growth has Shanahan seen in Robert Saleh after return?
(25:10) Greg Papa shares key matchups vs. Arizona
(29:12) Matt and Greg discuss 49ers’ banged-up offensive line
(32:44) Can 49ers’ improved speed on defense contain Kyler Murray?


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